## Table | Target | Full Name | Description | Evidence Level | | ---------------------------------- | --------------------------------------------- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | -------------- | | IGFr [[Insulin Growth Factor IGF]] | Insulin-Like Growth Factor Receptors | XYZ | XYZ | | IGF-2 | | | | | ASS1 | Argininosuccinate Synthase 1 | | | | AR | Androgen Receptor | XYZ | | | [[B7H3 (CD276)]] | | '96% of DSRCT samples were found to exhibit notable cell-surface expression of the immunomodulatory molecule B7H3, which has limited expression in normal tissue' [Link](https://pmc.ncbi.nlm.nih.gov/articles/PMC5614508/) Contributes to immuno-evasion and is a potential antigen target for therapy. Inhibits CD8 T Cell Response. Some miRNA's affect B7H3 expression. | | | [[EZH2 / PRC2]] | | | | | [[VEGF]] | Vascular Endothelial Growth Factor (receptor) | Angiogenesis | | | [[PDGFR]] | Platelet Derived Growth Factor (receptor) | Angiogenesis | | | [[BCL2]] | | Apoptosis evasion | | | [[DNA Damage Repair]] | | | | | [[PARP1]] | | | | | [[NTRK3 / TRKc]] | | | | | [[ASCL1]] | | Neural Reprogramming Factor. **EWS-WT1 oncoprotein activates neuronal reprogramming factor ASCL1 and promotes neural differentiation (2014)** | | | [[HDAC, Methylation]] | | | | | [[LSD1]] | | | | | | | | |