[[Website Project Log]] # Areas of Research **Biological Dimensions:** - **Scale**: Molecular → Cellular → Tissue → Organism → Population - **Process Type**: Metabolism, Signaling, Transcription, Translation, Cell Death, etc. - **Temporal**: Development, Homeostasis, Disease Progression, Treatment Response - **Functional Role**: Oncogenes, Tumor Suppressors, Metabolic Enzymes, Structural Proteins **Research Dimensions:** - **Evidence Type**: In vitro, In vivo, Clinical, Computational - **Study Design**: Mechanistic, Observational, Therapeutic, Diagnostic - **Confidence Level**: Well-established, Emerging, Speculative, Conflicting **8.**       [**DSRCT Studies index**](#_5_DSRCT_Studies) **9.**       [**Summary tables**](#_6_Summary_Tables) **10.**    [**Oncogenesis – Initiation**](#_7_Oncogenesis_–) 10.1  Cell of Origin & implications **11.**    [**Pathology**](#_10._Pathology) 11.1  Reports & Observations 11.2  Fusion Gene transcripts – FISH 12.    Molecular Heterogeneity – Principles & Models 12.1  Post-translational modification 12.2  Transcription, transcription factors 12.3  Isoforms of the Fusion Protein +-KTS 13.    Cell Structure Disorder, DSRCT Plasticity etc 13.1  Differentiation – Undifferentiated state 13.2  EMT/MeRT (Sarcoma) (STAT3?) 14.    Metastasis 14.1  Motility, Adhesion 14.2  Invasion 14.3  EMT/MeRT (Sarcoma). STAT3 14.4  EPCAM 14.5  MMP’s? 15.    Tumour Microenvironment (TME) 15.1  Acidic TME 15.2  Angiogenesis 15.3  Hypoxia | HIF-1a 15.4  VEGF/VEGF-A 15.5  Inflammation 15.6  Immune microenvironment (Own topic?) 15.7  IL-2 / IL15Rβ 15.8  TGF-β 16.    DSRCT Microenvironment & Immune Evasion 16.1  Desmoplasia, Stroma 16.1.1         PDGFa 16.2  Fibrosis, scarring 16.3  CAFs, Macrophages and TAMs 16.4  IL-6 16.5  Immune Checkpoints DSRCT 16.5.1         B7H3 / CD276 (Checkpoint)   16.5.2         PD-1 (T cells, not tumor) 17.    Altered Metabolism – DSRCT & TME 17.1  Arginine / ASS1 gene 17.2  Immune system antagonistic metabolism 17.3  Tumor Cell Metabolism 17.4   ENT4 Equilibrative Nucleoside Transp. / PMAT 18.   Resistance of cell death 18.1  Evasion of apoptosis 18.2  DNA Damage Repair (DDR, Replication Stress) 18.3  CHK1 Checkpoint Kinase 1, CCND1 18.4  BCL2 (PARPi relevance) 18.5  DR4/DR5 Death receptor? 18.6  Senesensce 19.    Growth, Proliferation 19.1  Growth factors, protein kinases, cell signalling 19.2  DHT 19.3  IGF/IGF-1 19.4  AR Androgen Receptor 19.4.1         FOXM1 19.5  mTOR 19.6  PDGF-A / PDGFR-A 19.7  PI3K/Akt/mTOR pathway 19.8  MAPK 20.    Cell Surface – Recptors, RTKs 20.1  NTRK3 / TrkC 21.    Autophagy - Contextual 22.    Immune system (large topic, perhaps separate?) 22.1  Immune metabolism considerations / similarity to cancer metabolism – care 22.2  STAT3 23.    NTRK3 / TRKc 23.1  BAIAP3? 23.2  ERBB/HER2 24.    Cancer Stem Cells (CSC) 25.    Circadian rhythm system disruptions 26.    Other targets of investigation 26.1  LIF 26.1.1         LIF & miRNA-21. IL-6 rel? 26.2  MLF-1 26.3  EGR-1 / ZNF268 / NGFI-A 26.4  ETS Transcription Factor 26.5  FGFR4 26.6  SLFN11 Schlafen-11 26.7  SIK1 Salt Inducible Kinase 26.8  mRNA, MiRNA, RISCs. circRNA’s 26.9  p53 # [[Fundamentals - Holistic Theories and Frameworks|Science Fundamentals and Principles of Thought]] Holistic Theories & Frameworks. Metaphors. Evolutionary and Ecological principles [[Different Preclinical Research Models in the lab and their consequences]]