Normal text paragraph - The pink “ropes” wrapping nests of small blue cells are collagen-rich **desmoplastic stroma** - a hallmark of DSRCT. This dense fibrosis is why resected masses often look **white/tan** and firm on gross exam.
Block quote text
> DSRCT cells are primitive and multiphenotypic, expressing epithelial (cytokeratins, EMA), mesenchymal (vimentin, desmin), and neural markers simultaneously[61](https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-13-585#:~:text=commonly%20fuses%20exon%207%20of,1). Histologically, they form nests of small “round blue” cells with scant cytoplasm, set in a desmoplastic stroma. The malignant cells typically have _no_ true glandular or muscular differentiation – they remain in an embryonic-like state. This undifferentiated nature contributes to aggressive invasion and metastasis. EMT, a process where epithelial traits are lost in favor of motile mesenchymal characteristics, is thought to facilitate DSRCT dissemination across serosal surfaces.
Block quote inline HTML line is \<span class="quote-cite"> to source and link on bottom line:
Text to display, then link comes in via \<a href="pubmed.com">TEXTOFLINK\</a>\</span>
\> <span class="quote-cite">Text for displaying here e.g Nature 2024
followed immediately by the link as \[Link_display_text_here] eg PMID XXXX
followed by (link) eg:
\[text](link)
If that doesn't work force it with the html inline version - a href
\<a href="https://pubmed.ncbi.nlm.nih.gov/XXXXX"
\> <span class="quote-cite">Source_name eg Nature (2024), <a href="https://pubmed.ncbi.nlm.nih.gov/XXXXX">PMID:XXXXX</a></span>
Explanation-
[[Not found - PubMed](https://pubmed.ncbi.nlm.nih.gov/XXXXX)]
> “EWS–WT1 drives …”
> — <span class="quote-cite">Nature (2024), <a href="https://pubmed.ncbi.nlm.nih.gov/XXXXX">PMID:XXXXX</a></span>
> “EWS–WT1 drives …”
> <span class="quote-cite">Nature 2024, [PMID:XXXXX](https://pubmed.ncbi.nlm.nih.gov/XXXXX)</span>
> DSRCT cells are primitive and multiphenotypic, expressing epithelial (cytokeratins, EMA), mesenchymal (vimentin, desmin), and neural markers simultaneously[61](https://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-13-585#:~:text=commonly%20fuses%20exon%207%20of,1). Histologically, they form nests of small “round blue” cells with scant cytoplasm, set in a desmoplastic stroma. The malignant cells typically have _no_ true glandular or muscular differentiation – they remain in an embryonic-like state. This undifferentiated nature contributes to aggressive invasion and metastasis. EMT, a process where epithelial traits are lost in favor of motile mesenchymal characteristics, is thought to facilitate DSRCT dissemination.
> <span class="quote-cite">Nature, 2024, [PMID:XXXXX](https://pubmed.ncbi.nlm.nih.gov/XXXXX)</span>
\> XYZTEXTEXAMPLE
\> -<span class="quote-cite">Nature, 2024, [PMID:XXXXX](https://pubmed.ncbi.nlm.nih.gov/XXXXX)</span>
Lists
-1dfidh
-2jiib
- 1
- 2
- 3
# Headings formatting
# Heading 1
## Heading 2
### Heading 3
#### Heading 4
##### Heading 5
###### Heading 6
# Heading 1
Normal text paragraph - The pink “ropes” wrapping nests of small blue cells are collagen-rich **desmoplastic stroma** - a hallmark of DSRCT. This dense fibrosis is why resected masses often look **white/tan** and firm on gross exam.
## Heading 2
Normal text paragraph - The pink “ropes” wrapping nests of small blue cells are collagen-rich **desmoplastic stroma** - a hallmark of DSRCT. This dense fibrosis is why resected masses often look **white/tan** and firm on gross exam.
### Heading 3
Normal text paragraph - The pink “ropes” wrapping nests of small blue cells are collagen-rich **desmoplastic stroma** - a hallmark of DSRCT. This dense fibrosis is why resected masses often look **white/tan** and firm on gross exam.
#### Heading 4
Normal text paragraph - The pink “ropes” wrapping nests of small blue cells are collagen-rich **desmoplastic stroma** - a hallmark of DSRCT. This dense fibrosis is why resected masses often look **white/tan** and firm on gross exam.
##### Heading 5
Normal text paragraph - The pink “ropes” wrapping nests of small blue cells are collagen-rich **desmoplastic stroma** - a hallmark of DSRCT. This dense fibrosis is why resected masses often look **white/tan** and firm on gross exam.
###### Heading 6
Normal text paragraph - The pink “ropes” wrapping nests of small blue cells are collagen-rich **desmoplastic stroma** - a hallmark of DSRCT. This dense fibrosis is why resected masses often look **white/tan** and firm on gross exam.
## Proxima Nova font types loaded:
### Text classes inline HTML span classes
light-text \<span class="light-text">
<span class="light-text">This text is light weight. The EWS-FLI1 fusion protein has phase transition properties, allowing it to transition into liquid-like, phase separated compartments consisting of membrane-less organelles. This phase transition property allows the fusion protein to access and activate micro-satellite regions of the genome that would otherwise be inaccessible</span>
medium-text \<span class="medium-text">
<span class="medium-text">This text is medium weight. DNA methylation leads to gene silencing as it prevents transcription factor binding. EWS-FLI1 reduces DNA methylation (which occurs mostly in areas corresponding to transcription enhancers), leading to increased gene expression.</span>
Regular
Transcription factors like WT1 and protein kinases especially being more amenable to the oncofusion process and causing cancer due to still being able to function with their oncoproteins post fuse.
*Regular italic*
*Love this study. Looks at fusion genes as fusion oncogenes and the interactions of their protein coding functions post fuse.*
**Bold** \**
**Alternatively, a proto-oncogene is fused to a strong promoter, and thereby the oncogenic function is upregulated due to the strong promoter of the upstream fusion partner.**
***Bold italic*** \***
<span class="black-text"> Black text </span> \<span class="black-text">
<span class="black-text">phase separated compartments
This phase transition property</span>
## Opentype features
### Small Caps (smcp)
small-caps \<span class="small-caps"> text_here \</span>
<span class="small-caps">This text is small caps</span> useful for things like <span class="small-caps">DNA RNA </span>
### Tabular numbers (tnum)
tabular-nums \<span class="tnum"> \</span>
<span class="tnum"> 0123456789 </span>
0123456789 (non-tabular)
### Fractions (frac) fractions
font-variant or font-variant-numeric subproperty: diagonal-fractions
\<span class='"diagonal-fractions"> \</span>
font-feature-settings: frac
\<span class='"frac"> \</span>
<span class ="frac">1 3/4 2 1/2 cups of flour etc 55/8 </span>
### Ordinals (ordn)
ordinal \<span class="ordn"> \</span>
<span class="ordn"> 1st, 2nd, 3rd, 54th etc </span>
### Supercript (sups)
superscript \<span class="sups"> \</span>
Good for citations etc<span class="sups">1</span> zya<span class="sups">2</span> yyy<span class="sups">3</span>
### Subscript (subs)
subscript \<span class="subs"> \</span>
Good for citations etc<span class="subs">1</span> zya<span class="subs">2</span> yyy<span class="subs">3</span>
## Callout types:
### Standard Obsidian
List of callouts:
\> [!note]+
\> [!abstract]+
\> [!info]+
\> [!tip]+
\> [!success]+
\>[!question]+
\> [!warning]+
\> [!failure]+
\> [!danger]+
\> [!bug]+
\> [!example]+
\> [!quote]+
\> [!note]+
> [!note]+
Normal text paragraph - The pink “ropes” wrapping nests of small blue cells are collagen-rich **desmoplastic stroma** - a hallmark of DSRCT. This dense fibrosis is why resected masses often look **white/tan** and firm on gross exam.
\> [!abstract]+
> [!abstract]+
> Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive small round blue cell malignancy which occurs predominantly in adolescent and young adult males, and is characterized by abdominopelvic sarcomatosis exhibiting multi-lineage cellular nests of epithelial, muscular, mesenchymal, and neural differentiation admixed with desmoplastic stroma[1](https://pmc.ncbi.nlm.nih.gov/articles/PMC8293793/#R1). The exact incidence of DSRCT is poorly defined, although since its histopathologic description at least 850 cases have been reported in the literature[2](https://pmc.ncbi.nlm.nih.gov/articles/PMC8293793/#R2). Overall survival at 5 years from retrospective series ranges from 11%[3](https://pmc.ncbi.nlm.nih.gov/articles/PMC8293793/#R3),[4](https://pmc.ncbi.nlm.nih.gov/articles/PMC8293793/#R4) to 28%[5](https://pmc.ncbi.nlm.nih.gov/articles/PMC8293793/#R5),[6](https://pmc.ncbi.nlm.nih.gov/articles/PMC8293793/#R6).
\> [!info]+
> [!info]+
> You can use several callout types and aliases. Each type comes with a different background color and icon.
\> [!tip]+
> [!tip]+
> Normal text paragraph - The pink “ropes” wrapping nests of small blue cells are collagen-rich **desmoplastic stroma** - a hallmark of DSRCT. This dense fibrosis is why resected masses often look **white/tan** and firm on gross exam.
\> [!success]+
> [!success]+
> Normal text paragraph - The pink “ropes” wrapping nests of small blue cells are collagen-rich **desmoplastic stroma** - a hallmark of DSRCT. This dense fibrosis is why resected masses often look **white/tan** and firm on gross exam.
\>[!question]+
>[!question]+
>Normal text paragraph - The pink “ropes” wrapping nests of small blue cells are collagen-rich **desmoplastic stroma** - a hallmark of DSRCT. This dense fibrosis is why resected masses often look **white/tan** and firm on gross exam.
\> [!warning]+
> [!warning]+
> Normal text paragraph - The pink “ropes” wrapping nests of small blue cells are collagen-rich **desmoplastic stroma** - a hallmark of DSRCT. This dense fibrosis is why resected masses often look **white/tan** and firm on gross exam.
\> [!failure]+
> [!failure]+
> Normal text paragraph - The pink “ropes” wrapping nests of small blue cells are collagen-rich **desmoplastic stroma** - a hallmark of DSRCT. This dense fibrosis is why resected masses often look **white/tan** and firm on gross exam.
\> [!danger]+
> [!danger]+
> Normal text paragraph - The pink “ropes” wrapping nests of small blue cells are collagen-rich **desmoplastic stroma** - a hallmark of DSRCT. This dense fibrosis is why resected masses often look **white/tan** and firm on gross exam.
\> [!bug]+
> [!bug]+
> Normal text paragraph - The pink “ropes” wrapping nests of small blue cells are collagen-rich **desmoplastic stroma** - a hallmark of DSRCT. This dense fibrosis is why resected masses often look **white/tan** and firm on gross exam.
\> [!example]+
> [!example]+
> Normal text paragraph - The pink “ropes” wrapping nests of small blue cells are collagen-rich **desmoplastic stroma** - a hallmark of DSRCT. This dense fibrosis is why resected masses often look **white/tan** and firm on gross exam.
\> [!quote]+
> [!quote]+
> Normal text paragraph - The pink “ropes” wrapping nests of small blue cells are collagen-rich **desmoplastic stroma** - a hallmark of DSRCT. This dense fibrosis is why resected masses often look **white/tan** and firm on gross exam.
# Reference
HTML Span classes
| Text | Span |
| ----------- | --------------------------- |
| Light text | \<span class="light-text"> |
| Medium test | \<span class="medium-text"> |
| | |
| | |
| | |
Truetype features
| Text | Span | ref |
| --------------- | -------------------------- | --- |
| Small Caps | \<span class="light-text"> | |
| Tabular Figures | \<span class="tnum"> | |
| | | |
| | | |
# Images HTML
\<img src="image_path.jpg" alt="description" width="400">
eg \<img src="OceanMap_Arctic.jpg" alt="description" width="400">
<img src="OceanMap_Arctic.jpg" alt="description" width="400">
Display inline class img-inline
\`<a href="Note-1.md"><img src="card1.png" alt="…" class="img-inline img-200"></a>`
Image classes 04 Sep 25-
**Fractions of container width - % scale**
.img-25
.img-33
.img-50
.img-66
.img-75
.img-100
**Pixel based width**
.img-200
.img-240
.img-400
.img-600
.img-800
**Optional: center images when smaller than text column**
img-center
Stack classes with a space
class="img-50 img-center"
<img src="test1.jpg" alt=" " class="img-50 img-center">
Display in an inline grid:
\div class="img-row"
\<div class="img-row">
\<a href="INSERT_LINK">
\<img src="IMAGE.png" alt="ALT_TEXT" class="img-200">
\</a>
\<a href="INSERT_LINK">
\<img src="IMAGE.png" alt="ALT_TEXT" class="img-200">
\</a>
\</div>
<div class="img-row">
<a href="INSERT_LINK">
<img src="test1.jpg" alt="ALT_TEXT" class="img-200">
</a>
<a href="INSERT_LINK">
<img src="test1.jpg" alt="ALT_TEXT" class="img-200">
</a>
</div>
Examples-
Width 300 -
\<img src="test1.jpg" alt=" " width="300">
<img src="test1.jpg" alt=" " width="300">
Width class 25%
\<img src="test1.jpg" alt="qtr width" class = "img-25">
<img src="test1.jpg" alt="qtr width" class = "img-25">
Width class 200
<img src="test1.jpg" alt="qtr width" class = "img-200"> <img src="test1.jpg" alt="qtr width" class = "img-200"> <img src="test1.jpg" alt="qtr width" class = "img-200">
<img src="test1.jpg" alt="qtr width" class = "img-200">
<img src="test1.jpg" alt="qtr width" class = "img-200">
Normal markdown embed
![[Test1.jpg]]
TEST GRID 337
<div class="img-grid">
<a href="Resisting%20Cell%20Death.md">
<img src="resisting cell death.png" alt="Resisting Cell Death">
</a>
<a href="Avoiding%20Immune%20Destruction.md">
<img src="avoiding immune destruction.png" alt="Avoiding Immune Destruction">
</a>
<a href="LINK">
<img src="replicative immortality.png" alt="replicative immortality">
</a>
</div>