![[EWSR1_Gene.png|420]] **Exons 1-7:** The first 7 exons encode the N-terminal domain of EWS, which consists of a repeated degenerated polypeptide of 7 to 12 residues rich in tyrosine, serine, threonine, glycine, and glutamine. **Exons 11-13:** Exons 11, 12, and 13 encode the putative RNA binding domain. The three glycine- and arginine-rich motifs of the gene are mainly encoded by exons 8-9, 14, and 16. The DNA sequence in the 5' region of the gene has features of a CpG-rich island and lacks canonical promoter elements, such as TATA and CCAAT consensus sequences. _EWS_ encodes a putative RNA binding protein, which together with TLS/FUS and TAFII68/TAF15 form the TET family of proteins with presumptive roles in transcription and splicing [8](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394657/#pone.0002353-Bertolotti1). ### EWS Protein - Wild Type > The EWS1 gene encodes a ubiquitous 656-amino acid protein. EWS1 comprises an N-terminal domain homologous to eukaryotic RNA polymerase II and a C-terminal domain homologous to RNA-binding domains ([42](https://www.sciencedirect.com/science/article/pii/S002192581984365X#bib42)). The common feature of these oncogenic proteins, thus, is the presence of the highly potent transcriptional activation N-terminal domain of EWS1 fused to a novel DNA binding domain. > [The IGF-I Receptor Gene Promoter Is a Molecular Target for the Ewing's Sarcoma-Wilms' Tumor 1 Fusion Protein (1996)](https://www.sciencedirect.com/science/article/pii/S002192581984365X)